Viscosity in Pharmaceutical Development
The problem
Viscosity data can tell you a ton about your sample up and down the development pipeline. In the world of antibody engineering and formulation, viscosity raises the alarm when your antibody is prone to sticky self-interactions or if your formulation isn’t going to cut it. In process development, high viscosity can lead to issues with tangential-flow filtration (TFF), sterile filtration, or high sample loss in other fill/finish processes. Viscosity is the biggest factor telling you if your sample will struggle with syringeability or injectability.
For such a useful measurement, most viscometers and rheometers are such a hassle that no one is getting as much viscosity data as they need. High-volume, classic techniques can require hours of hands-on time in super slow, one-sample-at-a-time instruments. Even modern tech that just needs microliters of sample is often paired with a ridiculously expensive chip that creates a one-by-one bottleneck and a constant cycle of clogging, cleaning, and calibration in pharmaceutical applications of viscosity.
The right tool for the job
Honeybun is the only walk-up-and-go system that pours out viscometry and rheometry data as fast as you can handle it. Microfluidic channels in the disposable Bun consumables mean viscosity data is only moments away for anyone with 35 µL of sample volume. With the capacity to run up to ten samples simultaneously and a software interface geared to skip the boring setup stuff, viscosity is simply sweet to run on any batch of samples or conditions. When you roll with Honeybun, you’ll finally stuff yourself with as much sweet viscosity data as you want.
The proof
Push it to the limit
Characterize every construct, formulation, and concentration by gathering as much viscosity data as you really want. Know which combinations behave the best, and exactly how high you can go in concentration before you’re over your viscosity limit.
Sweep up piles of data
Every read in Honeybun is done with a sweep of shear rates, so you’ll get to see if your viscosity is staying rock-solid or if there’s some non-Newtonian behavior going on.
Cool down
Cool temperatures can send viscosity straight to the moon. Honeybun lets you explore how samples behave at room temperature or when cooled down. If your manufacturing process has a warm spot, you can also heat up Honeybun to get a spot-on value at higher temps.
Honeybun
Honeybun is the sweetest viscometer and rheometer out there. It rolls together the unbeatable combination of microliter sample volumes, simultaneous reads of up to ten samples, short run times, disposable consumables, and software that’s a cakewalk. With Honeybun you can see if any sample resists all kinds of pressure or is ready to go with the flow.
Want more info?
Want to learn more about how Honeybun rolls out tons of sweet viscosity data?